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1047 problems

Open problems

Each problem states how progress is verified and what counts as a contribution. Besides the problems curated here, the catalogue includes open conjectures from Formal Conjectures (with Lean statements), optimization constants and the AlphaEvolve problems. Know one that belongs here? Propose a problem.

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1047 shown· page 2 of 21

B Combinatorics

Small van der Waerden numbers

Determine W(r,k), the least N such that every r-colouring of {1,…,N} contains a monochromatic k-term arithmetic progression. Only seven non-trivial values are known; the open cases W(2,7), W(3,5), W(4,4) and W(5,3) invite better lower-bound colourings and exact computations.

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B Graph theory

The degree–diameter problem for graphs

Find the largest graphs with maximum degree d and diameter k. Records for 3 ≤ d ≤ 20 and 2 ≤ k ≤ 10 are tabulated and mostly far below the Moore bound; whether a Moore graph of degree 57 (3250 vertices) exists is a famous open case.

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C Astrophysics & cosmology

The origin of fast radio bursts

Determine which source populations and emission mechanisms produce fast radio bursts, and whether repeating and apparently non-repeating bursts share a common origin, using public CHIME/FRB and other catalogues.

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A Graph theory

The Ramsey number R(4,6)

Narrow the gap 36 ≤ R(4,6) ≤ 40. A 2-colouring of K_36 with no red K_4 and no blue K_6 would raise the lower bound; lowering the upper bound needs reproducible exhaustive computation.

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B Combinatorics

The sixth Schur number S(6)

Find the largest N such that {1,…,N} can be split into six sum-free sets. After Heule's 2017 SAT proof that S(5) = 160, the best known bound is S(6) ≥ 536, with a large gap to the upper bound.

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C Hard Algorithms

Approximation ratio and integrality gap for metric TSP

Find better polynomial-time approximation algorithms for the metric Traveling Salesman Problem and prove the conjectured 4/3 integrality gap of the subtour LP. The best known ratio is 3/2 − ε with ε > 10^−36 (Karlin–Klein–Oveis Gharan).

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B Hard Number theory

Do odd perfect numbers exist?

Decide whether an odd perfect number exists. Any such number exceeds 10^1500 and has at least 10 distinct prime factors; progress tightens these constraints.

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C Hard Complexity

Explicit rigid matrices (Valiant's rigidity problem)

Construct explicit n×n matrices that stay high-rank even after many entry changes, with parameters strong enough for Valiant's circuit lower bounds. Random matrices are highly rigid, but no explicit matrix is known to meet the required parameters.

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C Hard Combinatorics

Frankl's union-closed sets conjecture

Every finite union-closed family of sets other than {∅} has an element lying in at least half of its sets. Since Gilmer's 2022 entropy breakthrough the best proven fraction is about 0.38; closing the gap to 1/2 is open.

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C Hard Number theory

Legendre's conjecture

Prove that there is always a prime between n^2 and (n+1)^2. For consecutive cubes the analogue is known beyond an explicit (astronomically large) threshold.

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B Hard Biology

RNA 3D structure prediction

Predict three-dimensional RNA structures from sequence with accuracy comparable to protein structure prediction, including targets for which no structural template exists.

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C Hard Astrophysics & cosmology

Small-scale problems of cold dark matter

Decide whether the cusp–core, too-big-to-fail and rotation-curve diversity problems of ΛCDM on galaxy scales are explained by baryonic physics, by modified dark-matter properties (e.g. self-interactions), or by observational systematics.

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