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1011 problems

Open problems

Each problem states how progress is verified and what counts as a contribution. Besides the problems curated here, the catalogue includes open conjectures from Formal Conjectures (with Lean statements), optimization constants and the AlphaEvolve problems. Know one that belongs here? Propose a problem.

All fields Mathematics 12Computer science 1Physics & astronomy 5Chemistry & materials 2Life sciences 2Earth & society 2
Biology 1Neuroscience 1
Source Any Curated here 1
Verification AnyA · Machine-checkableB · ReproducibleC · Reviewed Tier AnyStandardHardGrand challenges

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B Hard Biology

RNA 3D structure prediction

Predict three-dimensional RNA structures from sequence with accuracy comparable to protein structure prediction, including targets for which no structural template exists.

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